TL-20-495B84 SYGNOMICS Report
01/09/2022
SOC Drugs
# 1. Target: GSR
Drugs
Model Evidence
6 regulons containing the target(s), GSR are overactive in this patient.
Hallmarks Enrichment
None
Literature Evidence
Glioblastoma Clinical Trials
Network Plots
Drugs in GBM Trials
# 1. Target: FNTA,FNTB
Drugs
Model Evidence
15 regulons containing the target(s), FNTA,FNTB are overactive in this patient.
Hallmarks Enrichment
Literature Evidence
Glioblastoma Clinical Trials
Network Plots
2. Target: ALDH2
Drugs
Model Evidence
2 regulons containing the target(s), ALDH2 are overactive in this patient.
Hallmarks Enrichment
None
Literature Evidence
No additional evidence was found
Glioblastoma Clinical Trials
Network Plots
3. Target: JAK1,JAK2
Drugs
Model Evidence
24 regulons containing the target(s), JAK1,JAK2 are overactive in this patient.
Hallmarks Enrichment
None
Literature Evidence
No additional evidence was found
Glioblastoma Clinical Trials
Network Plots
FDA Approved Drugs
# 1. Target: KCNK3
Drugs
Model Evidence
2 regulons containing the target(s), KCNK3 are overactive in this patient.
Hallmarks Enrichment
None
Literature Evidence
No additional evidence was found
Glioblastoma Clinical Trials
No glioblastoma clinical trials were found for these drugs.
Network Plots
2. Target: SLC6A1
Drugs
Model Evidence
3 regulons containing the target(s), SLC6A1 are overactive in this patient.
Hallmarks Enrichment
None
Literature Evidence
No additional evidence was found
Glioblastoma Clinical Trials
No glioblastoma clinical trials were found for these drugs.
Network Plots
3. Target: ADORA1
Drugs
Model Evidence
4 regulons containing the target(s), ADORA1 are overactive in this patient.
Hallmarks Enrichment
None
Literature Evidence
No additional evidence was found
Glioblastoma Clinical Trials
No glioblastoma clinical trials were found for these drugs.
Network Plots
4. Target: JAK2
Drugs
Model Evidence
20 regulons containing the target(s), JAK2 are overactive in this patient.
Hallmarks Enrichment
None
Literature Evidence
No additional evidence was found
Glioblastoma Clinical Trials
No glioblastoma clinical trials were found for these drugs.
Network Plots
5. Target: JAK1
Drugs
Model Evidence
4 regulons containing the target(s), JAK1 are overactive in this patient.
Hallmarks Enrichment
None
Literature Evidence
No additional evidence was found
Glioblastoma Clinical Trials
No glioblastoma clinical trials were found for these drugs.
Network Plots
6. Target: ABL1
Drugs
Model Evidence
5 regulons containing the target(s), ABL1 are overactive in this patient.
Hallmarks Enrichment
Literature Evidence
Glioblastoma Clinical Trials
No glioblastoma clinical trials were found for these drugs.
Network Plots
7. Target: JAK1,JAK2
Drugs
Model Evidence
24 regulons containing the target(s), JAK1,JAK2 are overactive in this patient.
Hallmarks Enrichment
None
Literature Evidence
No additional evidence was found
Glioblastoma Clinical Trials
No glioblastoma clinical trials were found for these drugs.
Network Plots
8. Target: RTN4
Drugs
Model Evidence
3 regulons containing the target(s), RTN4 are overactive in this patient.
Hallmarks Enrichment
None
Literature Evidence
No additional evidence was found
Glioblastoma Clinical Trials
No glioblastoma clinical trials were found for these drugs.
Network Plots
9. Target: FNTA,FNTB
Drugs
Model Evidence
15 regulons containing the target(s), FNTA,FNTB are overactive in this patient.
Hallmarks Enrichment
Literature Evidence
Glioblastoma Clinical Trials
Network Plots
10. Target: MAPK1,MAPK3
Drugs
Model Evidence
20 regulons containing the target(s), MAPK1,MAPK3 are overactive in this patient.
Hallmarks Enrichment
None
Literature Evidence
No additional evidence was found
Glioblastoma Clinical Trials
Network Plots
11. Target: BACE1
Drugs
Model Evidence
1 regulons containing the target(s), BACE1 are overactive in this patient.
Hallmarks Enrichment
None
Literature Evidence
No additional evidence was found
Glioblastoma Clinical Trials
No glioblastoma clinical trials were found for these drugs.
Network Plots
12. Target: NDUFA13
Drugs
Model Evidence
5 regulons containing the target(s), NDUFA13 are overactive in this patient.
Hallmarks Enrichment
HALLMARK_OXIDATIVE_PHOSPHORYLATION HALLMARK_DNA_REPAIR HALLMARK_MYC_TARGETS_V1
Literature Evidence
Glioblastoma Clinical Trials
No glioblastoma clinical trials were found for these drugs.
Network Plots
13. Target: TSG101
Drugs
Model Evidence
2 regulons containing the target(s), TSG101 are overactive in this patient.
Hallmarks Enrichment
HALLMARK_OXIDATIVE_PHOSPHORYLATION HALLMARK_DNA_REPAIR HALLMARK_MYC_TARGETS_V1
Literature Evidence
Glioblastoma Clinical Trials
No glioblastoma clinical trials were found for these drugs.
Network Plots
14. Target: VAMP2
Drugs
Model Evidence
2 regulons containing the target(s), VAMP2 are overactive in this patient.
Hallmarks Enrichment
None
Literature Evidence
No additional evidence was found
Glioblastoma Clinical Trials
No glioblastoma clinical trials were found for these drugs.
Network Plots
15. Target: NQO1
Drugs
Model Evidence
2 regulons containing the target(s), NQO1 are overactive in this patient.
Hallmarks Enrichment
Literature Evidence
No additional evidence was found
Glioblastoma Clinical Trials
No glioblastoma clinical trials were found for these drugs.
Network Plots
16. Target: TRPV4
Drugs
Model Evidence
1 regulons containing the target(s), TRPV4 are overactive in this patient.
Hallmarks Enrichment
None
Literature Evidence
No additional evidence was found
Glioblastoma Clinical Trials
No glioblastoma clinical trials were found for these drugs.
Network Plots
17. Target: HSPA8
Drugs
Model Evidence
29 regulons containing the target(s), HSPA8 are overactive in this patient.
Hallmarks Enrichment
None
Literature Evidence
No additional evidence was found
Glioblastoma Clinical Trials
No glioblastoma clinical trials were found for these drugs.
Network Plots
18. Target: ABAT
Drugs
Model Evidence
16 regulons containing the target(s), ABAT are overactive in this patient.
Hallmarks Enrichment
None
Literature Evidence
No additional evidence was found
Glioblastoma Clinical Trials
No glioblastoma clinical trials were found for these drugs.
Network Plots
19. Target: GSR
Drugs
Model Evidence
6 regulons containing the target(s), GSR are overactive in this patient.
Hallmarks Enrichment
None
Literature Evidence
Glioblastoma Clinical Trials
No glioblastoma clinical trials were found for these drugs.
Network Plots
20. Target: ATP1A1
Drugs
Model Evidence
63 regulons containing the target(s), ATP1A1 are overactive in this patient.
Hallmarks Enrichment
HALLMARK_UV_RESPONSE_DN HALLMARK_APOPTOSIS HALLMARK_EPITHELIAL_MESENCHYMAL_TRANSITION HALLMARK_TGF_BETA_SIGNALING HALLMARK_COMPLEMENT HALLMARK_TNFA_SIGNALING_VIA_NFKB
Literature Evidence
No additional evidence was found
Glioblastoma Clinical Trials
No glioblastoma clinical trials were found for these drugs.
Network Plots
21. Target: SOD1
Drugs
Model Evidence
5 regulons containing the target(s), SOD1 are overactive in this patient.
Hallmarks Enrichment
Literature Evidence
No additional evidence was found
Glioblastoma Clinical Trials
No glioblastoma clinical trials were found for these drugs.
Network Plots
22. Target: ACVR2B
Drugs
Model Evidence
5 regulons containing the target(s), ACVR2B are overactive in this patient.
Hallmarks Enrichment
Literature Evidence
No additional evidence was found
Glioblastoma Clinical Trials
No glioblastoma clinical trials were found for these drugs.
Network Plots
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